Research interests

  • Peptidomimetics (peptide mimics) interacting with bacterial membranes
  • Protein aggregates (e.g., oligomers and fibrils) interacting with lipid membranes
  • Phase separation in model lipid bilayers
  • Viral peptides modulate lipid membrane curvature and structure 

Research Examples

  • Phase separation of lipid bilayers revealed by atomic force microscopy.

  • Giant unilamellar vesicles acting as a platform for observing phase separation. The two images below were obtained using fluorescence microscopy.

  • Toxic protein aggregates interacting with lipid bilayers.

  • Micropipette aspiration of giant unilamellar vesicles. This technique is useful to reveal kinetic impacts of active molecules on vesicle morphology and integrity.

  • Imaging bacterial morphology using atomic force microscopy

Research Support

Award number: 1R15GM117531-01 (12/01/2015 – 11/30/2018)

Title: Characterizing Interactions between Bacterial Membranes and Peptidomimetics for the Development of Antibiotics Targeting Multidrug Resistant Bacteria